Scientific Publications

2024

Olmedo CG, Beltrán LD, García VM, Ferrer JLP, Jiménez AC, Cubero RU, del Palacio JP, Díaz C, Vicente F, Rovira PS. Assessment of Untargeted Metabolomics by Hydrophilic Interaction Liquid Chromatography−Mass Spectrometry to Define Breast Cancer Liquid Biopsy-Based Biomarkers in Plasma Samples. International Journal of Molecular Sciences. 2024; 25(10):5098. https://doi.org/10.3390/ijms25105098 Abstract

Álvarez-León F, Rosado-Aguilar JA, Gamboa-Angulo M, Flota-Burgos GJ, Martin J, Reyes F. Anthelmintic activity and chemical profile of native plant extracts from the Yucatan Peninsula against Toxocara canis. Acta Tropica. 2024 Jul;255:107214. doi: 10.1016/j.actatropica.2024.107214 Abstract

Jennings LK, Kaur N, Ramos MC, Reyes F, Reddy MM, Thomas OP. Highly Concentrated Linear Guanidine Amides from the Marine Sipunculid Phascolosoma granulatum. Journal of Natural Products. 2024. DOI: 10.1021/acs.jnatprod.3c01186   Abstract

Domingo-Contreras E, Tormo JR, González V, Mackenzie TA, Martín-Serrano J, Magiera-Mularz K, Kitel R, Reyes F, Genilloud O, Fernández R, Ramos MC, Castillo F. Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction. International Journal of Biological Macromolecules, Volume 264, Part 1, 2024, 130458. https://doi.org/10.1016/j.ijbiomac.2024.130458. Abstract

García-Gutiérrez C, Pérez-Victoria I, Montero I, Fernández-De la Hoz J, Malmierca MG, Martín J, Salas JA, Olano C, Reyes F, Méndez C. Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces sp. CS113. International Journal of Molecular Sciences. 2024; 25(4):2347. https://doi.org/10.3390/ijms25042347 Abstract

Fernández-Pastor I, Ortiz-López FJ, Oves-Costales D, Martín J, Sánchez P, Melguizo Á, Reyes F, Weber T, Genilloud O. Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca2+-Binding Motif. Organic Letters. 2024 Feb 23;26(7):1343-1347. doi: 10.1021/acs.orglett.3c04195. Abstract

Vitorino IR, Pinto E, Martín J, Mackenzie TA, Ramos MC, Sánchez P, de la Cruz M, Vicente F, Vasconcelos V, Reyes F, Lage OM. Uncovering the biotechnological capacity of marine and brackish water Planctomycetota. Antonie Van Leeuwenhoek. 2024 Jan 23;117(1):26. doi: 10.1007/s10482-023-01923-z.  Abstract

Mackenzie TA, Reyes F, Martínez M, González-Menéndez V, Sánchez I, Genilloud O, Tormo JR, Ramos MC. Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells. Molecules. 2024; 29(2):425. https://doi.org/10.3390/molecules29020425 Abstract

Cabello-Donayre M, Cabello-Donayre I, Guerra D, Orrego LM, Morales JC, Cautain B, Vicente F, Pérez-Victoria JM. A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity. International Journal of Antimicrobial Agents. 2024 Mar;63(3):107092. doi: 10.1016/j.ijantimicag.2024.107092. Abstract

González-Olmedo C, García-Verdejo FJ, Reguera-Teba A, Rosa-Garrido C, López-López JA, Díaz-Beltrán L, García PM, Luque-Caro N, Gálvez-Montosa F, Ortega-Granados AL, Ruiz-Sanjuan M, Cózar-Ibáñez A, Sainz J, Marchal JA, Camacho J, Del Palacio JP, Fernández-Godino R, Díaz C, Sánchez-Rovira P. Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis. Clinical and Translational Medicine. 2024 Jan;14(1):e1541. doi: 10.1002/ctm2.1541. Abstract

Dos Santos JDN, Pinto E, Martín J, Vicente F, Reyes F, Lage OM. Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary. International Microbiology. 2024 Jan 18. doi: 10.1007/s10123-024-00483-0.  Abstract

Peña-Martín J, García-Ortega MB, Palacios-Ferrer JL, Díaz C, Ángel García M, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias Santiago S, Vicente F, Del Val C, Pérez Del Palacio J, Marchal JA. Identification of novel biomarkers for early diagnosis of malignant melanoma by untargeted LC-HRMS-based metabolomics: a pilot study. British Journal of Dermatology. 2024 Jan 12:ljae013. doi: 10.1093/bjd/ljae013. Abstract

Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Oves-Costales D, Martín J, Murillo-Alba J, Tormo JR, Cho A, Byun SY, No JH, Shum D, Ioset JR, Genilloud O, Reyes F. Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents? International Journal of Molecular Sciences. 2023 Dec 25;25(1):301. doi: 10.3390/ijms25010301. Abstract

Santos JDND, Klimek D, Calusinska M, Lobo-da-Cunha A, Catita J, Gonçalves H, González I, Lage OM. Microbacterium memoriense sp. nov., a member of the Actinomycetota from marine beach sediment of the north coast of Portugal. International Journal of Systematic and Evolutionary Microbiology. 2024 Jan;74(1). doi: 10.1099/ijsem.0.006230. Abstract

Matias-Valiente L, Sanchez-Fernandez C, Rodriguez-Outeiriño L, Ramos MC, Díaz C, Crespo G, González-Menéndez V, Genilloud O, Reyes F, Montolio M, Hernandez-Torres F, Aranega AE. Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy. Biomedicine & Pharmacotherapy. Volume 170, January 2024, 116056. doi: 10.1016/j.biopha.2023.116056.  Abstract

2023

O’Brien S, Lacret R, Reddy MM, Jennings LK, Sánchez P, Reyes F, Mungkaje A, Calabro K, Thomas OP. Additional Sarasinosides from the Marine Sponge Melophlus sarasinorum Collected from the Bismarck Sea. Journal of Natural Products, 2023, https://doi.org/10.1021/acs.jnatprod.3c01045  Abstract

Martínez-Arribas B, Annang F, Díaz-González R, Pérez-Moreno G, Martín J, Mackenzie TA, Castillo F, Reyes F, Genilloud O, Ruiz-Pérez LM, Vicente F, Ramos MC, González-Pacanowska D. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. Microbiology Spectrum. DOI: https://doi.org/10.1128/spectrum.01679-23  Abstract

Resa S, González M, Reyes F, Pérez-Victoria I. Revision of the full stereochemistry of telomycin. Organic Chemistry Frontiers, 2023, https://doi.org/10.1039/D3QO01411H  Abstract

Matilla MA, Evans TJ, Martín J, Udaondo Z, Lomas-Martínez C, Rico-Jiménez M, Reyes F, Salmond GPC. Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi. Microbial Biotechnology. 2023; 16:c 1690-1700. https://ami-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.14193  Abstract

Santamaría RI, Martínez-Carrasco A, Tormo JR, Martín J, Genilloud O, Reyes F, Díaz M. Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes. International Journal of Molecular Sciences. 2023; 24(21):15659. https://doi.org/10.3390/ijms242115659 Abstract

Thomas A. Mackenzie, José R. Tormo, Bastien Cautain, Germán Martínez, Isabel Sánchez, Olga Genilloud, Francisca Vicente, Maria C. Ramos. Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products. SLAS Technology, 2023, ISSN 2472-6303, https://doi.org/10.1016/j.slast.2023.10.003  Abstract

Fernández-Pastor I, González-Menéndez V, Martínez Andrade K, Serrano R, Mackenzie TA, Benítez G, Casares-Porcel M, Genilloud O, Reyes F. Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides. Journal of Fungi. 2023; 9(9):887. https://doi.org/10.3390/jof9090887  Abstract

Bagán A, Rodriguez-Arévalo S, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Brocos-Mosquera I, Callado LF, Morales-García JA, Pérez B, Diaz C. Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease. Pharmaceutics. 2023; 15(10):2381. https://doi.org/10.3390/pharmaceutics15102381  Abstract

Serrano R, González-Menéndez V, Tormo JR, Genilloud O. Development and Validation of a HTS Platform for the Discovery of New Antifungal Agents against Four Relevant Fungal Phytopathogens. Journal of Fungi. 2023; 9(9):883. https://doi.org/10.3390/jof9090883  Abstract

Kokkini M, Oves-Costales D, Sánchez P, Melguizo Á, Mackenzie TA, Pérez-Bonilla M, Martín J, Giusti A, de Witte P, Vicente F, Genilloud O, Reyes F. New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains. Marine Drugs. 2023 Aug 7;21(8):443. doi:10.3390/md21080443. Abstract

Huang W, Rodrigues J, Bilgo E, Tormo JR, Challenger JD, De Cozar-Gallardo C, Pérez-Victoria I, Reyes F, Castañeda-Casado P, Gnambani EJ, Hien DFS, Konkobo M, Urones B, Coppens I, Mendoza-Losana A, Ballell L, Diabate A, Churcher TS, Jacobs-Lorena M. Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes. Science. 2023 Aug 4;381(6657):533-540. doi: 10.1126/science.adf8141. Abstract

Rodríguez-Ruiz M, Ramos MC, Campos MJ, Díaz-Sánchez I, Cautain B, Mackenzie TA, Vicente F, Corpas FJ, Palma JM. Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles. Antioxidants. 2023; 12(7):1461. https://doi.org/10.3390/antiox12071461  Abstract

Palma JM, Pérez del Palacio J, Rodríguez-Ruiz M, González-Gordo S, Caridad Díaz C, Ramos MC, Cautain B, Vicente F, Corpas FJ (2023). Nitric Oxide in Health and Disease. Therapeutic Applications in Cancer and Inflammatory Disorders (Morbidelli L, Bonavida B, Muntané J, eds.) pp. 193-210, Chapter 8 - Pepper fruit, as a nutraceutical food, shows antiproliferative activity against tumor cells and it is potentiatied by nitric oxide (NO). Academic Press-Elsevier. https://doi.org/10.1016/B978-0-443-13342-8.00012-0 Abstract

Ye S, Molloy B, Pérez-Victoria I, Montero I, Braña AF, Olano C, Arca S, Martín J, Reyes F, Salas JA, Méndez C. Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome. International Journal of Molecular Sciences. 2023 May 3;24(9):8197. doi: 10.3390/ijms24098197. Abstract

Gaudêncio SP, Bayram E, Lukić Bilela L, Cueto M, Díaz-Marrero AR, Haznedaroglu BZ, Jimenez C, Mandalakis M, Pereira F, Reyes F, Tasdemir D. Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Marine Drugs. 2023 May 19;21(5):308. doi: 10.3390/md21050308. Abstract

Ortiz-López F J, Oves-Costales D, Carretero-Molina D, Martín J, Díaz C, de la Cruz M, Román-Hurtado F, Álvarez-Arévalo M, Jørgensen T, Reyes F, Weber T, Genilloud O. Crossiellidines A–F, Unprecedented Pyrazine-Alkylguanidine Metabolites with Broad-Spectrum Antibacterial Activity from Crossiella sp. Organic Letters. 2023, May 10. https://doi.org/10.1021/acs.orglett.3c01088 Abstract

Molina-Tijeras JA, Ruiz-Malagón AJ, Hidalgo-García L, Diez-Echave P, Rodríguez-Sojo MJ, Cádiz-Gurrea MdlL, Segura-Carretero A, del Palacio JP, González-Tejero MR, Rodríguez-Cabezas ME, Gálvez J, Rodríguez-Nogales A, Vezza T, Algieri F. The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice. Antioxidants. 2023; 12(4):832. https://doi.org/10.3390/antiox12040832 Abstract

Deisinger JP, Arts M, Kotsogianni I, Puls JS, Grein F, Ortiz-López FJ, Martin NI , Müller A, Genilloud O, Schneider T. Dual targeting of the class V lanthipeptide antibiotic cacaoidin. iScience. 2023 Mar 11;26(4):106394. doi: 10.1016/j.isci.2023.106394. Abstract

Durcik M, Cotman A E, Toplak Z, Možina S, Skok Ž, Szili P E, Czikkely M, Maharramov E, Vu TH, Piras M V, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo L A, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol S V, Jin Z, Vicente F, Ramos M C, Mundy J E A, Maxwell A, Stevenson C A M, D M Lawson, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen G V, Sterk G J, Kikelj D, Pal C, Tomašič T, Mašič L P. New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus. Journal of Medicinal Chemistry. 2023 66 (6), 3968-3994 DOI: 10.1021/acs.jmedchem.2c01905  Abstract

Acebedo-Martínez FJ, Alarcón-Payer C, Verdugo-Escamilla C, Martín J, Frontera A, Domínguez-Martín A, Gómez-Morales J, Choquesillo-Lazarte D. Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals. Pharmaceuticals. 2023; 16(3):370. https://doi.org/10.3390/ph16030370 Abstract

Annang FB, Pérez-Moreno G, Bosch-Navarrete C, González-Menéndez V, Martín J, Mackenzie TA, Ramos MC, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171. Pharmaceutics. 2023; 15(2):492. https://doi.org/10.3390/pharmaceutics15020492 Abstract

Sánchez-Hidalgo M, García MJ, González I, Oves-Costales D, Genilloud O. Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters. Microorganisms. 2023; 11(2):265. https://doi.org/10.3390/microorganisms11020265   Abstract

Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6. Abstract

Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. Journal of Medicinal Chemistry. 2023 Jan 12. doi: 10.1021/acs.jmedchem.2c01597  Abstract

Gattoni G, de la Haba RR, Martín J, Reyes F, Sánchez-Porro C, Feola A, Zuchegna C, Guerrero-Flores S, Varcamonti M, Ricca E, Selem-Mojica N, Ventosa A and Corral P. Genomic study and lipidomic bioassay of Leeuwenhoekiella parthenopeia: A novel rare biosphere marine bacterium that inhibits tumor cell viability. Frontiers in Microbiology. 13:1090197. doi: 10.3389/fmicb.2022.1090197 Abstract

Oves-Costales D, Gren T, Baggesgaard Sterndorff E, Martín J, Ortiz-López FJ, Jørgensen TS, Jiang X, Román-Hurtado F, Reyes F, Genilloud O, Weber T. Identification and heterologous expression of the globomycin biosynthetic gene cluster. Synthetic and Systems Biotechnology. Volume 8, Issue 2, 2023, Pages 206-212. https://doi.org/10.1016/j.synbio.2023.02.001. Abstract

Diyaolu OA, Preet G, Fagbemi AA, Annang F, Pérez-Moreno G, Bosch-Navarrete C, Adebisi OO, Oluwabusola ET, Milne BF, Jaspars M, Ebel R. Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria. Antibiotics (Basel). 2023 Jan 6;12(1):109. doi: 10.3390/antibiotics12010109  Abstract

2022

dos Santos JDN, João SA, Martín J, Vicente F, Reyes F, Lage OM. iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments. Microorganisms. 2022; 10(7):1471. https://doi.org/10.3390/microorganisms10071471 Abstract

Jimenez L, Amenabar C, Mayoral-Varo V, Mackenzie TA, Ramos MC, Silva A, Calissi G, Grenho I, Blanco-Aparicio C, Pastor J, Megías D, Ferreira BI, Link W. mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity. Molecules. 2022; 27(17):5414. https://doi.org/10.3390/molecules27175414 Abstract

Rodríguez-Ruiz M, Ramos C, Campos MJ, Vicente F, Corpas FJ, Palma JM. Crude extracts from pepper fruits show anti-proliferative activity against tumor cells altering their catalase and glucose-6-phosphate dehydrogenase profile. Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 40-41. https://doi.org/10.1016/j.freeradbiomed.2022.06.172 Abstract

Rodríguez-Ruiz M, Pérez de Palacio J, González-Gordo S, Díaz C, Ramos C, Vicente F, Palma JM, Corpas FJ. Compounds from sweet pepper (Capsicum annuum l.) fruits with potential therapeutic uses are boosted by nitric nitric oxide (NO). Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 41, https://doi.org/10.1016/j.freeradbiomed.2022.06.173 Abstract

Virués-Segovia JR, Reyes F, Ruíz S, Martín J, Fernández-Pastor I, Justicia C, de la Cruz M, Díaz C, Mackenzie TA, Genilloud O, González I, Tormo JR. Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens. Molecules. 2022; 27(19):6355. https://doi.org/10.3390/molecules27196355 Abstract

Riccio G, Martinez KA, Martín J, Reyes F, D'Ambra I, Lauritano C. Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds. Marine Drugs. 2022 May 25;20(6):350. doi: 10.3390/md20060350. Abstract

Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P. Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp. ACS Chemical Biology. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Abstract

Liang H, Lopez IJ, Sánchez-Hidalgo M, Genilloud O, van der Donk WA. Mechanistic Studies on Dehydration in Class V Lanthipeptides. ACS Chemical Biology. 2022 Sep 16;17(9):2519-2527. doi: 10.1021/acschembio.2c00458 Abstract

Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6 Abstract

Pérez-Victoria I, Crespo G, Reyes F. Expanding the utility of Marfey's analysis by using HPLC-SPE-NMR to determine the Cβ configuration of threonine and isoleucine residues in natural peptides. Analytical and Bioanalytical Chemistry. 2022 Nov;414(28):8063-8070. doi: 10.1007/s00216-022-04339-2 Abstract

Navarro JA, Díaz C, Decara J, Medina-Vera D, Lopez-Gambero AJ, Suarez J, Pavón FJ, Serrano A, Vargas A, Gavito AL, Porras-Perales O, Aranda J, Vicente F, Sanjuan C, Baixeras E, Fonseca FR. Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers. Nutrients. 2022 Oct 1;14(19):4094. doi: 10.3390/nu14194094 Abstract

Ye S, Ballin G, Pérez-Victoria I, Braña AF, Martín J, Reyes F, Salas JA, Méndez C. Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus. Applied Microbiology International. 2022 Nov 8. doi: 10.1111/1751-7915.14167 Abstract

Sarmiento-Vizcaíno A, Martín J, Ortiz-López FJ, Reyes F, García LA, Blanco G. Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin. Frontiers in Chemistry. 2022 Nov 3;10:948795. doi: 10.3389/fchem.2022.948795 Abstract

Vitorino IR, Lobo-da-Cunha A, Vasconcelos V, Vicente F, Lage OM. Isolation, diversity and antimicrobial activity of planctomycetes from the Tejo river estuary (Portugal). FEMS Microbiology Ecology, fiac066, https://doi.org/10.1093/femsec/fiac066.  Abstract

Ortiz-Gonzalez M, Pérez-Victoria I, Ramirez-Macias I, De Pedro N, Linde-Rodriguez A, González-Menéndez V, Sanchez-Martin V, Martín J, Soriano-Lerma A, Genilloud O, Perez-Carrasco V, Vicente F, Maceira J, Rodrígues-Poveda CA, Navarro-Marí JM, Reyes F, Soriano M, Garcia-Salcedo JA. Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription. International Journal of Molecular Sciences. 2022; 23(11):6107. https://doi.org/10.3390/ijms23116107 Abstract

Santamaría R I, Martínez-Carrasco A, Martín J, Tormo J R, Pérez-Victoria I, González I, Genilloud O, Reyes F, Díaz M. Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp. Antibiotics. 2022, 11(5), 672; https://doi.org/10.3390/antibiotics11050672  Abstract

Bagán A, Morales-García JA, Griñán-Ferré C, Díaz C, Pérez del Palacio J, Ramos MC, Vicente F, Pérez B, Brea J, Loza MI, Pallàs M, Escolano C. Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06. International Journal of Molecular Sciences. 2022; 23(10):5408. https://doi.org/10.3390/ijms23105408 Abstract

Riccio G, Martinez KA, Ianora A, Lauritano C. De Novo Transcriptome of the Flagellate Isochrysis galbana Identifies Genes Involved in the Metabolism of Antiproliferative Metabolites. Biology. 2022; 11(5):771. https://doi.org/10.3390/biology11050771  Abstract

Reyes F, Bills GF, Durán-Patrón R. Editorial: Strategies for the Discovery of Fungal Natural Products. Frontiers in Microbiology. 2022, Vol. 13. DOI=10.3389/fmicb.2022.897756.  Abstract

Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Natural Product Research. 2022 Apr;36(8):2043-2048. doi:10.1080/14786419.2020.1844699.  Abstract

Slemc L, Jakše J, Filisetti A, Baranasic D, Rodríguez-García A, Del Carratore F, Marino SM, Zucko J, Starcevic A, Šala M, Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Reyes F, Genilloud O, Springthorpe V, Goranovič D, Kosec G, Thomas GH, Lucrezia D, Petković H, Tome M. Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing. Microbiology Spectrum. 2022 Apr 4:e0243421. doi: 10.1128/spectrum.02434-21. Abstract

Machushynets N, Elsayed S, Du C, Siegler M, de la Cruz M, Genilloud O, Hankemeier T, van Wezel G. Discovery of actinomycin L, a new member of the actinomycin family of antibiotics. Scientific Reports, (2022), 2813, 12(1). https://doi.org/10.1038/s41598-022-06736-0 Abstract

Martinez JC, Castillo F, Ruiz-Sanz J, Murciano-Calles J, Camara-Artigas A, Luque I. Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families. Advances in Protein Chemistry and Structural Biology. ELSEVIER. 2022 Jan 10. https://doi.org/10.1016/bs.apcsb.2021.12.002.  Abstract

Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147. Applied and Environmental Microbiology, 2022;88:e01839-21 https://journals.asm.org/doi/10.1128/AEM.01839-21  Abstract

Carretero-Molina D, Ortiz-López FJ, Gren T, Oves-Costales D, Martín J, Román-Hurtado F, Jørgensen TS, de la Cruz M, Díaz C, Vicente F, Blin K, Reyes F, Weber T, Genilloud O. Discovery of gargantulides B and C, new 52-membered macrolactones from Amycolatopsis sp. Complete absolute stereochemistry of the gargantulide family. Organic Chemistry Frontiers 2022; 9:462-70. https://doi.org/10.1039/D1QO01480C  Abstract

Martínez KA, Saide A, Crespo G, Martín J, Romano G, Reyes F, Lauritano C, Iannora A. Promising Antiproliferative Compound from the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells. Frontiers in Marine Science 2022; 9:778108. https://doi.org/10.3389/fmars.2022.778108  Abstract

Gimranov E, Santos JDN, Vitorino I, Martín J, Reyes F, Moura L, Tavares F, Santos C, Mariz-Ponte N, Lage OM. Marine bacterial activity against phytopathogenic Pseudomonas show high efficiency of Planctomycetes extracts. European Journal of Plant Pathology 2022; 162:843-54. https://doi.org/10.1007/s10658-021-02441-2  Abstract

Díaz C, González-Olmedo C, Díaz-Beltrán L, Camacho J, Mena García P, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Marchal JA, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Predicting Dynamic response to neoadjuvant chemotherapy in breast cancer: a novel metabolomics approach. Molecular Oncology. 2022 Mar 26. doi: 10.1002/1878-0261.13216. Abstract

Ganesan A, Aldholmi M, Ahmad R, Carretero-Molina D, Pérez-Victoria I, Martín J, Reyes F, Genilloud O, Gourbeyre L, Gefflaut T, Carlsson H, Maklakov A, Field RA, O'Neill E, Wilkinson B, O'Connell M. Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis. Angewandte Chemie International Edition. 2022 Mar 24. doi: 10.1002/anie.202203175.  Abstract

Schnegotzki R, Wiebach V, Sánchez-Hidalgo M, Tietzmann M, Zur Bonsen AB, Genilloud O, Süssmuth RD. Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I. Organic Letters. 2022 Mar 21. doi: 10.1021/acs.orglett.2c00525.  Abstract

Pérez I, Campos-Pardos E, Díaz C, Uranga S, Sayes F, Vicente F, Aguiló N, Brosch R, Martín C, Gonzalo-Asensi J. The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy. Molecular Therapy: Nucleic Acids. 2022, Vol. 27 1235 – 1248. DOI: https://doi.org/10.1016/j.omtn.2022.02.011  Abstract

Castillo F, Corbi-Verge C, Murciano-Calles J, Candel A m, Han Z, Iglesias-Bexiga M, Ruiz-Sanz J, Kim P M, Harty R n, Martinez J C, Luque I. Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals. International Journal of Biological Macromolecules, 2022. Volume 207, 15 May 2022, Pages 308-323. DOI: https://doi.org/10.1016/j.ijbiomac.2022.03.010. Abstract

Georgousaki K, González-Menéndez V, Tormo JR, Tsafantakis N, Mackenzie TA,
Martín J, Gumeni S, Trougakos IP, Reyes F, Fokialakis N, Genilloud O. Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants. Scientifc Reports. 2022 Jan 31;12(1):1649. doi: 10.1038/s41598-022-05448-9.  Abstract

Moo-Koh FA, Cristóbal-Alejo J, Andrés MF, Martín J, Reyes F, Tun-Suárez JM, Gamboa-Angulo M. In Vitro Assessment of Organic and Residual Fractions of Nematicidal Culture Filtrates from Thirteen Tropical Trichoderma Strains and Metabolic Profiles of Most-Active. Journal of Fungi (Basel). 2022 Jan 15;8(1):82. doi: 10.3390/jof8010082. Abstract

Wang X, Serrano R, González-Menéndez V, Mackenzie TA, Ramos MC, Frisvad JC, Larsen TO. A Molecular Networking Based Discovery of Diketopiperazine Heterodimers and Aspergillicins from Aspergillus caelatus. Journal of Natural Products. 2022 Jan 28;85(1):25-33. doi: 10.1021/acs.jnatprod.1c00526.  Abstract

Miguel-Gordo M, Reddy MM, Sánchez P, Buckley JJ, Mackenzie TA, Jennings LK, Reyes F, Calabro K, Thomas OP. Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands. Organic & Biomolecular Chemistry. 2022 Jan 12. doi: 10.1039/d1ob02297k. Abstract

Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enfermedades infecciosas y microbiologia clinica (English ed.). 2022 Jan;40(1):14-21. doi: 10.1016/j.eimce.2020.06.019. Abstract

2021

Álvarez-Caballero JM, Cuca-Suárez LE, Coy-Barrera E, Carrasco-Pancorbo A, Olmo-García L, Martin J, Cruz M, Peŕez-Victoria I, Reyes F. Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea. American Chemical Society Omega. 2021 Nov 23;6(48):32631-32636. doi: 10.1021/acsomega.1c04255.  Abstract

Annang F, Pérez-Moreno G, Díaz C, González-Menéndez V, de Pedro Montejo N, Del Palacio JP, Sánchez P, Tanghe S, Rodriguez A, Pérez-Victoria I, Cantizani J, Ruiz-Pérez LM, Genilloud O, Reyes F, Vicente F, González-Pacanowska D. Preclinical evaluation of strasseriolides A-D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251. Malar J. 2021 Dec 5;20(1):457. doi: 10.1186/s12936-021-03993-8. Abstract

Sarmiento-Vizcaíno A, Martín J, Reyes F, García LA, Blanco G. Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain. Front Microbiol. 2021, 12:773095. Abstract

Beck C, Gren T, Ortiz-López FJ, Jørgensen T S, Carretero-Molina D, Martín Serrano J, Tormo JR, Oves-Costales D, Kontou E E, Mohite OS, Mingyar E, Stegmann E, Genilloud O, Weber T. Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods. Molecules 2021, 26, 6580. Abstract

Vitorino I, Santos JDN, Godinho O, Vicente F, Vasconcelos V, Lage OM. Novel and Conventional Isolation Techniques to Obtain Planctomycetes from Marine Environments. Microorganisms. 2021 Oct 1;9(10):2078. doi: 10.3390/microorganisms9102078. Abstract

Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, novel halogenated hybrid PKS-NRPS compounds produced by Streptomyces sp. CS147. Appl Environ Microbiol. 2021 Oct 20:AEM0183921. doi: 10.1128/AEM.01839-21. Abstract

Oluwabusola ET, Adebisi OO, Reyes F, Acquah KS, De La Cruz M, Mweetwa LL, Rajakulendran JE, Warner DF, Hai D, Ebel R, Jaspars M. Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B. Beilstein J Org Chem. 2021 Sep 13;17:2390-2398.
doi: 10.3762/bjoc.17.156. Abstract

Díaz C, Jiménez-Luna C, Diéguez-Castillo C, Martín A, Prados J, Martín-Ruíz JL, Genilloud O, Vicente F, Pérez Del Palacio J, Caba O. Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis. Medicina (Kaunas). 2021 Aug 26;57(9):876. doi: 10.3390/medicina57090876. Abstract

Jørgensen TS, Gren T, Oves-Costales D, Ortiz-López FJ, Carretero-Molina D, González I, Blin K, Genilloud O, Weber T. Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a 35-Module Type I Polyketide Synthase. Microbiol Resour Announc. 2021 Sep 23;10(38):e0080521. doi: 10.1128/MRA.00805-21. Abstract

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Towards the sustainable discovery and development of new antibiotics. Nat Rev Chem. 2021 Aug 19:1-24. doi: 10.1038/s41570-021-00313-1.  Abstract

Jørgensen TS, Gren T, Kontou EE, González I, Román-Hurtado F, Oves-Costales D, Thomsen E, Charusanti P, Genilloud O, Weber T. Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp. Strain CA-103260. Microbiol Resour Announc. 2021 Jul 29;10(30):e0049921. doi: 10.1128/MRA.00499-21.  Abstract

Kontou EE, Gren T, Ortiz-López FJ, Thomsen E, Oves-Costales D, Díaz C, de la Cruz M, Jiang X, Jørgensen TS, Blin K, Charusanti P, Reyes F, Genilloud O, Weber T. Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260. ACS Chem Biol. 16(8):1456-1468. doi: 10.1021/acschembio.1c00318.  Abstract

Juhasz B, Pech-Puch D, Tabudravu JN, Cautain B, Reyes F, Jiménez C, Kyeremeh K, Jaspars M. Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV-Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1 T. Mar Drugs. 2021 Jun 3;19(6):325. doi: 10.3390/md19060325.  Abstract

Del Carratore F, Iorio M, Pérez-Bonilla M, Schmidt K, Pérez-Redondo R, Sosio M, Macdonald SJ, Gyulev IS, Tsigkinopoulou A, Thomas GH, Genilloud O, Rodríguez-García A, Donadio S, Breitling R, Takano E. Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A. mSystems. 6(3):e0034121. doi: 10.1128/mSystems.00341-21. Abstract

Serrano R, González-Menéndez V, Martínez G, Toro C, Martín J, Genilloud O, Tormo R. Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach. Molecules. 2021; 26(14):4262. https://doi.org/10.3390/molecules26144262 Abstract

Beck C, Gren T, Jørgensen TS, González I, Román-Hurtado F, Oves-Costales D, Genilloud O, Weber T. Complete Genome Sequence of Streptomyces sp. Strain CA-256286. Microbiol Resour Announc. 2021 Jun 3;10(22):e0029021. doi:10.1128/MRA.00290-21.  Abstract

Breitling R, Avbelj M, Bilyk O, Carratore FD, Filisetti A, Hanko EKR, Iorio M, Redondo RP, Reyes F, Rudden M, Severi E, Slemc L, Schmidt K, Whittall DR, Donadio S, García AR, Genilloud O, Kosec G, De Lucrezia D, Petković H, Thomas G,Takano E. Synthetic biology approaches to actinomycete strain improvement. FEMS Microbiol Lett. 2021 Jun 11;368(10): fnab060. doi: 10.1093/femsle/fnab060.  Abstract

Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán-Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi:10.1021/acs.biomac.0c01546.  Abstract

Guevara L, Domínguez-Anaya MÁ, Ortigosa A, González-Gordo S, Díaz C, Vicente F, Corpas FJ, Pérez Del Palacio J, Palma JM. Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO). Int J Mol Sci. 2021 Apr 25;22(9):4476. doi: 10.3390/ijms22094476.  Abstract

Guo Y, Ding L, Ghidinelli S, Gotfredsen CH, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Coriani S, Larsen RW, Frisvad JC, Larsen TO. Taxonomy Driven Discovery of Polyketides from Aspergillus californicus. J Nat Prod. 2021 Apr 23;84(4):979-985. doi: 10.1021/acs.jnatprod.0c00866.  Abstract

Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. Antibiotics, (2021), 403, 10(4) doi: 10.1101/2020.05.20.105809. Abstract

Cebrero-Cangueiro T, Labrador-Herrera G, Pascual Á, Díaz C, Rodríguez-Baño J, Pachón J, del Palacio JP, Pachón-Ibáñez ME and Conejo MC . Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains. Front. Med. 8:615540. doi: 10.3389/fmed.2021.615540.  Abstract

Carretero-Molina D, Ortiz-López FJ, Martín J, González I, Sánchez-Hidalgo M, Román-Hurtado F, Díaz C, de la Cruz M, Genilloud O, Reyes F. Pentaminomycins F and G, Nonribosomal Peptides Containing 2-Pyridylalanine. J Nat Prod. 2021 , 84, 4, 1127-1134. doi: 10.1021/acs.jnatprod.0c01199. Epub ahead of print.   Abstract

Herath KB, Previs SF, Roddy TP, Attygalle AB, González I, Genilloud O, Singh SB. Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry. J Nat Prod. 2021 Mar 26;84(3):814-823. doi: 10.1021/acs.jnatprod.0c01190.   Abstract

Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán- Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi: 10.1021/acs.biomac.0c01546.   Abstract

Fernández-Pastor, I.; González-Menéndez, V.; Annang, F.; Toro, C.; Mackenzie, T.A.; Bosch-Navarrete, C.; Genilloud, O.; Reyes, F. Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals 2021, 14, 268. https://doi.org/10.3390/ph14030268, 14(3), 268;  Abstract

Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, Gonzalez-Menendez V, Genilloud O, Trougakos IP, Fokialakis N, Ouazzani J. Elastase inhibitory activity of secondary metabolites from the fungus Virgaria nigra CF-231658. Nat Prod Res. 2021 Mar 11:1-4. doi: 10.1080/14786419.2021.1899175.  Abstract

Rotter A, Barbier M, Bertoni F, Bones AM, Cancela ML, Carlsson J, Carvalho MF, Cegłowska M, Chirivella-Martorell J, Conk DM, Cueto M, Dailianis T, Deniz I, Díaz-Marrero AR, Drakulovic D, Dubnika A, Edwards C, Einarsson H, Erdoan A, Eroldoan OT, Ezra D, Fazi S, FitzGerald RJ, Gargan LM, Gaudêncio SP, Gligora UM, Ivosevic DeNardis N, Jónsdóttir R, Katarzytė M, Klun K, Kotta J, Ktari L, Ljubesic Z, Lukic Bilela L, Mandalakis M, Massa-Gallucci A, Matijosytė I, Mazur-Marzec H, Mehiri M, Nielsen Søren L, Novoveská L, Overlingė D, Perale G, Ramasamy P, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Röttinger E, Rudovica V, Sabotic J, Safarik I, Talve S, Tasdemir D, Theodotou Schneider X, Thomas OP, Toruńska-Sitarz A, Varese GC, Vasquez MI. The Essentials of Marine Biotechnology. Front. Mar. Sci., (2021), 158, 8. DOI:10.3389/fmars.2021.629629. Abstract

Silvestri A, Vicente F, Vicent MJ, Stechmann B, Fecke W. Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery. Drug Discov Today. (2021) 1369-1381, 26(6). doi: 10.1016/j.drudis.2021.02.024.  Abstract

García-Padilla C, Lozano-Velasco E, López-Sánchez C, Garcia-Martínez V, Aranega A, Franco D. Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers. Noncoding RNA. 2021 Feb 17;7(1):13. doi: 10.3390/ncrna7010013.  Abstract

Palacios-Ferrer JL, García-Ortega MB, Gallardo-Gómez M, García MÁ, Díaz C, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias-Santiago S, Amezcua V, Peinado H, Vicente F, Pérez Del Palacio J, Marchal JA. Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma.Mol Oncol. 2021 Feb;15(2):407-428. doi: 10.1002/1878-0261.12823.  Abstract

Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot.  74, 111–114 (2021). doi: 10.1038/s41429-020-00372-4.  Abstract

Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk WA. New developments in RiPP discovery, enzymology and engineering. Nat. Prod. Rep., 2021,38, 130-239. doi: 10.1039/d0np00027b.  Abstract

Gavriilidou, A.; Mackenzie, T.A.; Sánchez, P.; Tormo, J.R.; Ingham, C.; Smidt, H.; Sipkema, D. Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria. Mar. Drugs 2021, 19, 75. https://doi.org/10.3390/md19020075  Abstract

Subko K, Wang X, Nielsen FH, Isbrandt T, Gotfredsen CH, Ramos MC, Mackenzie T, Vicente F, Genilloud O, Frisvad JC, Larsen TO. Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility. Front Microbiol. 2021 Jan 15;11:618730. doi: 10.3389/fmicb.2020.618730. Abstract

Subko K, Kildgaard S, Vicente F, Reyes F, Genilloud O, Larsen TO. Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria. Mar Drugs. 2021 Jan 20; 19(2), 46. doi: 10.3390/md19020046. Abstract

Díaz-Beltrán L, González-Olmedo C, Luque-Caro N, Díaz C, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer. Cancers (Basel). 2021 Jan 5;13(1):147. doi:10.3390/cancers13010147.  Abstract

Pérez-Victoria I. Co-occurring congeners reveal the position of enantiomeric amino acids in nonribosomal peptides. Chembiochem. 2021 Jan 13. doi: 10.1002/cbic.202000805.  Abstract

Méndez-Luna D, Morelos-Garnica LA, García-Vázquez JB, Bello M, Padilla-Martínez II, Fragoso-Vázquez MJ, Dueñas González A, De Pedro N, Gómez-Vidal JA,Mendoza-Figueroa HL, Correa-Basurto J. Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells. Pharmaceuticals (Basel). 2021 Jan 10;14(1):49. doi: 10.3390/ph14010049. Abstract

Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López FJ, Carretero-Molina D, Reyes F, Genilloud O. One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360. Microorganisms. 2021 Jan 8;9(1):135. doi: 10.3390/microorganisms9010135. Abstract

Elamine Y, Lyoussi B, Miguel MG, Anjos O, Estevinho L, Alaiz M, Girón-Calle J, Martín J, Vioque J. Physicochemical characteristics and antiproliferative and antioxidant activities of Moroccan Zantaz honey rich in methyl syringate. Food Chem. 2021 Mar 1;339:128098. doi: 10.1016/j.foodchem.2020.128098. Abstract

2020

Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Nat Prod Res. 2020 Nov 9:1-6. doi: 10.1080/14786419.2020.1844699. Abstract

Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):423. doi: 10.3390/metabo10110423. Abstract

Calabro K, Jennings LK, Lasserre P, Doohan R, Rodrigues D, Reyes F, Ramos C, Thomas OP. Nebulosins: Trisubstituted Thiolane Natural Products from the Northeastern Atlantic Annelid Eupolymnia nebulosa. J Org Chem. 2020, 85, 21, 14026–14041. Abstract

Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):E423. Abstract

Cruz-Cerino P, Cristóbal-Alejo J, Ruiz-Carrera V, Carnevali G, Vera-Ku M, Martín J, Reyes F, Gamboa-Angulo M. Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense. Pathogens. 2020 Oct 10;9(10):E827. Abstract

Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot 74, 111–114 (2021). Abstract

Pérez-Bonilla M, Oves-Costales D, González I, de la Cruz M, Martín J, Vicente F, Genilloud O, Reyes F. Krisynomycins, Imipenem Potentiators against Methicillin-Resistant Staphylococcus aureus, Produced by Streptomyces canus. J Nat Prod. 2020, 83,9,2597-2606.  Abstract

Annang F, Pérez-Moreno G, González-Menéndez V, Lacret R, Pérez-Victoria I,Martín J, Cantizani J, de Pedro N, Choquesillo-Lazarte D, Ruiz-Pérez LM,González-Pacanowska D, Genilloud O, Vicente F, Reyes F. Strasseriolides A-D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251. Org Lett. 2020, 22, 17, 6709–6713. Abstract

Bekiesch P, Zehl M, Domingo-Contreras E, Martín J, Pérez-Victoria I, Reyes F, Kaplan A, Rückert C, Busche T, Kalinowski J, Zotchev SB. Viennamycins: Lipopeptides Produced by a Streptomyces sp. J. Nat. Prod. 2020, 83, 8, 2381–2389. Abstract

Diogo Santos J, Vitorino I, Reyes F, Vicente F, Lage O M. From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria. Antibiotics 2020, 9(8), 455; Abstract

Oluwabusola ET, Tabudravu JN, Al Maqbali KS, Annang F, Pérez-Moreno G, Reyes F, Jaspars M. Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax. Chem Biodivers. 2020 Jul 22. doi: 10.1002/cbdv.202000335. Abstract

Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enferm Infecc Microbiol Clin. 2020 Jul 13:S0213-005X(20)30233-0. Abstract

Sánchez-Hidalgo M, Pascual J, González I, Genilloud O. Draft Genome Sequenceand Biosynthetic Potential of the Newly Described Strain Longimicrobium terrae CB-286315. Microbiol Resour Announc. 2020 Jun 11;9(24):e00512-20. Abstract

Tienaho J, Karonen M, Muilu-Mäkelä R, Kaseva J, de Pedro N, Vicente F,Genilloud O, Aapola U, Uusitalo H, Vuolteenaho K, Franzén R, Wähälä K, Karp M,Santala V, Sarjala T. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020; 86(13/14): 1009-1024. Abstract

Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. bioRxiv. doi: 10.1101/2020.05.20.105809.  Abstract

Ortiz-López FJ, Carretero-Molina D, Sánchez-Hidalgo M, Martín J, González I, Román-Hurtado F, De la Cruz M, García-Fernández S, Reyes F, Deisinger JP, Müller A, Schneider T & Genilloud O. Cacaoidin, First Member of the New Lanthidin RiPP Family. Angewandte Chemie International Edition 2020; doi.org/10.1002/anie.202005187.  Abstract

Becerril A, Pérez-Victoria I, Ye S, Braña AF,Martín J, Reyes F, Salas JA, and Méndez C. Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family. ACS Chem. Biol. 2020, 15, 6, 1541–1553; Abstract

Corpas-López V, Tabraue-Chávez M, Sixto-López Y, Panadero-Fajardo S, Alves de Lima Franco F, Domínguez-Seglar JF, Morillas-Márquez F, Franco-Montalbán F, Díaz-Gavilán M, Correa-Basurto J, López-Viota J, López-Viota M, Pérez Del Palacio J, de la Cruz M, de Pedro N, Martín-Sánchez J, Gómez-Vidal JA. O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity. J Med Chem. 2020 Jun 11;63(11):5734-5751.
Abstract

Crespo G, Pérez-Victoria I, Ortiz-López FJ, González-Menéndez V, De la Cruz M, Cautain B, Sánchez P, Vicente F, Genilloud O and Reyes F. Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens. Antibiotics 2020, 9(6), 278. Abstract

Cabello-Donayre M, Orrego LM, Herráez E, Vargas P, Martínez-García M, Campos-Salinas J, Pérez-Victoria I, Vicente B, Marín JJG, Pérez-Victoria JM. Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite. Cell. Mol. Life Sci., 77, pages1827–1845(2020). Abstract

Rotter A, Bacu A, Barbier M, Bertoni F, Bones A M, Cancela M L, Carlsson J, Carvalho M F, Cegłowska M, Dalay M C, Dailianis T, Deniz I, Drakulovic D, Dubnika A, Einarsson H, Erdoğan A, Eroldoğan O T, Ezra D, Fazi S,FitzGerald R J, Gargan L M, Gaudêncio S P, DeNardis N I, Joksimovic D, Kataržytė M, Kotta J, Mandalakis M, Matijošytė I, Mazur-Marzec H, Massa-Gallucci A, Mehiri M, Nielsen S L, Novoveská L, Overlingė D, Portman M E, Pyrc K, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Rudovica V, Sabotič J, Safarik I, Talve S, Tasdemir D, Schneider X T, Thomas OP, Toruńska-Sitarz A, Varese G C, Vasquez . A new network for the advancement of marine biotechnology in Europe and beyond. Front. Mar. Sci., 2020; 7:278. Abstract

Martín-Blázquez A, Jiménez-Luna C,Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers, 2020, 12(4), 1002. Abstract

Berenguel Hernández A M., De la Cruz M, Alcázar-Fabra M, Prieto-Rodríguez A, Sánchez-Cuesta A, Martin J, Tormo J R, Rodríguez-Aguilera J C, Cortés-Rodríguez A B, Navas P, Reyes F, Vicente F, Genilloud O, Santos-Ocaña C. Design of high-throughput screening of natural extracts to identify molecules bypassing primary coenzyme Q deficiency in Saccharomyces cerevisiae. SLAS Discov., 2020, 25, 299-309. Abstract

Salamanca-Fernández E,Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque M D, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez del Palacio J, Olea N, Agudo A, Sánchez MJ. Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors. Environmental Research,2020, 182, 109012. Abstract

Lauritano C, Martínez K A, Battaglia P, Granata A, De la Cruz M, Cautain B, Martín J, Reyes F, Ianora A, Guglielmo L. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Sci Rep., 10, 4929 (2020).  Abstract

Diogo Santos J, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez I, Tormo J R, Martin J, Vicente MF, Lage OM. Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges. Antonie van Leeuwenhoek, 113, pages875–887(2020). Abstract

Sánchez-Hidalgo M, Martín J, Genilloud O. Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. Antibiotics, 2020, 9(2), 67.  Abstract

Georgousaki K, Tsafantakis N, Gumeni S, Lambrinidis G, González-Menéndez V, Tormo JR, Genilloud O, Trougakos IP, Fokialakis N. Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules. Molecules, 2020, 25(3), 666. Abstract

Fang Q , Maglangit F , Wu L, Ebel R, Kyeremeh K, Andersen JH, Annang F, Pérez-Moreno G,Reyes F, Deng H. Signalling and Bioactive Metabolites from Streptomyces sp. RK44, Molecules, 2020, 25(3), 460. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Generation of new sipanmycin analogues by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway. Appl. Environ. Microbiol., 2020, 86, e02453-19. Abstract

Georgousaki, K., Tsafantakis, N., Gumeni, S., Gonzalez, I., Andrew Mackenzie, T., Reyes F., Lambert, C., Trougakos, I.P., Genilloud, O., Fokialakis, N., Screening for tyrosinase inhibitors from actinomycetes; Identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor. Bioorg Med Chem Lett., 2020, 15;30(6):126952.  Abstract

Romain Koagne R, Annang F, Cautain B, Martín J, Pérez-Moreno G, Thierry M. Bitchagno G, González-Pacanowska D, Vicente F, Konga Simo I, Reyes F & Tane P. Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae). BMC Complementary Medicine and Therapies, 2020,15;20(1):8.  Abstract

Carretero-Molina D, Ortiz-López F J, Martín J, Oves-Costales D, Díaz C, De la Cruz M, Cautain B, Vicente F, Genilloud O, Reyes F. New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078. Mar. Drugs, 2020, 18(1), 22.  Abstract

Mazzotta S, Marrugal-Lorenzo J A, Vega-Holm M, Serna-Gallego A, Álvarez-Vidal J, Berastegui-Cabrera J, Pérez del Palacio J, Díaz C, Aiello F, Pachón J,Iglesias-Guerra F,Vega-Pérez J M, Sánchez-Céspedes J. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents. Eur J Med Chem., 2020, 1;185. Abstract

2019

Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Sci Rep., 9, 20198 (2019). Abstract

Almeida C, Mackenzie TA, González-Menendez V, De Pedro N, Pérez-Victoria I, Crespo G, Martín J, Genilloud O, Vicente F, Cautain B, Reyes F. Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp. PMIO, 2019; 6(02): e57-e62. Abstract

Barúa JE, De la Cruz M, De Pedro N, Cautain B, Hermosa R, Cardoza RE, Gutiérrez S, Monte E, Vicente F, Collado IG. Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities. Molecules, 2019, 24, 3811 Abstract

Tejman-Yarden N, Robinson A, Davidov Y, Shulman A, Varvak A, Reyes F, Rahav G, Nissan I. Delftibactin-A, a Non Ribosomal Peptide with Broad Antimicrobial Activity. Front. Microbiol., 10:2377  doi: 10.3389/fmicb.2019.02377.  Abstract

Reina JC, Pérez-Victoria I, Martín J, Llamas I. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar. Drugs, 2019, 17: 494. Abstract

González-Menéndez V, Crespo G, Toro C, Martín J, de Pedro N, Tormo JR, Genilloud O. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani. Metabolites, 2019, 9: 197. Abstract

Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J. Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules, 2019, 24: 2239. Abstract

Peyrat L-A, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N. Terrestrial Microorganisms: Cell Factories of  Bioactive Molecules with Skin Protecting  Applications. Molecules, 2019, 24: 1836. Abstract

Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N. Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor. J Biotechnol., 2019, 301: 88-96. Abstract

Martínez KA, Lauritano C, Druka D, Romano G, Grohmann T, Jaspars M, Martín J, Díaz C, Cautain B, de la Cruz M, Ianora A, Reyes F. Amphidinol 22, a new cytotoxic and antifungal amphidinol from the dinoflagellate Amphidinium carterae. Mar. Drugs, 2019, 17: 385. Abstract

Díaz C, Pérez del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS Infectious Diseases., 2019, 5: 1317-1326. Abstract

Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM. Bioactivities and Extract Dereplication of Actinomycetales isolated from Marine Sponges. Front Microbiol., 2019, 10: 727. Abstract

Pérez del Palacio J, Díaz-Navarro C, Martín-Blázquez A, González-Olmedo C, Vergara-Segura N, Algieri F, Rodriguez-Nogales A, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Rodríguez-Cabez MA. Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool. Plant. Biosyst., 2019, 154:231-240.  Abstract

Butassi E, Svetaz LA, Zhou S, Wolfender JL, G. Cortés JC, Ribas JC, Díaz-Navarro C, Pérez del Palacio J, Vicente F, Zacchino SA. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera.  Phytomedicine, 2019, 60: 152884.  Abstract

Martín J, Reyes F, Vicente F, Gamboa-Angulo M, Escalante-Réndiz D, De la Rosa García S, Tapia-Tussell R. Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity. Int J. Environ. Res. Public Health, 2019, 16: 1913. Abstract

Khentoul H, Bensouici C, Reyes F, Albanese D, Sarri D, Mekkiou R, Benayache F, Seghiri R, Boumaza O. Chemical constituents and HRESI-MS analysis of an Algerian endemic plant-Verbascum atlanticum Batt.- extracts and their antioxidant activity. Nat. Prod. Res., 2019, 22: 1-5.  Abstract

Guillen PO, Jaramillo KB, Jennings L, de la Cruz M, Cautain B, Reye Fs, Rodríguez J, Thomas OP. Halogenated tyrosine derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini. J. Nat. Prod., 2019, 82: 1354-1360. Abstract

Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P. Activation of secondary metabolite gene clusters in Streptomyces clavuligerus by the PimM regulator of Streptomyces natalensis. Front. Microbiol., 2019, 10: 580. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro. Mol. Pharm., 2019, 16: 1456-1466.   Abstract

Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B,   Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019, 17:2954-2971.  Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Gloria Blanco. Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Mar. Drugs, 2019, 17 (2) : 114. Abstract

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J,  Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M,  Specker E, Bartunek P, Simova S, Les´nikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, and Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discover., 2019, 24: 398-413.  Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2019, 33: 66-73 Abstract

Castillo F., Mackenzie T.A., Cautain B. Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous FOXO. Link W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, 2019, 1890: 143-149. Abstract

2018

Koagne RR, Annang F, de la Cruz M, Bitchagno GTM, Perez-Victoria I, Konga IS, Vicente F, Reyes F, Tane P. Antibacterial Activity of Flavans from Crinum distichum. Natural Product Communications 2018, 13 : 637-1638. Abstract

Genilloud O. Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? Antibiotics, 2018, 7: 85. Abstract

Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J. Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica. J. Nat. Prod., 2018, 81, 2301-2305. Abstract

Rodríguez V, J. Martín, A. Sarmiento-Vizcaíno, M. de la Cruz, L. A. García, G. Blanco, Reyes F. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169. Mar. Drugs, 2018, 16: 406. Full text

Ortiz-López FJ, Alcalde E, Sarmiento-Vizcaíno A, Díaz C, Cautain B, García, Blanco G, Reyes F. New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157. Mar. Drugs, 2018, 16: 371. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro. Neuropharmacology, 2018, 141: 283-295. Abstract

Solanki H, Angulo-Preckler C, Calabro K, Kaur N, Lasserre P, Cautain B, de la Cruz M, Reyes F, Avila C, Thomas OP. Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905). Tetrahedron Lett., 2018, 59: 3353-3356. Abstract

Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353. J. Nat. Prod., 2018, 81: 1687-1691. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA, Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149. Appl Environ Microbiol 84:e01462-18. Abstract

Li F, Janussen D, Peifer C, Pérez-Victoria I, Tasdemir D, Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity. Mar. Drugs 2018, 16, 268. Abstract

Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F. Current Screening Methodologies in Drug Discovery for Selected Human Diseases. Marine Drugs. 2018; 16(8):279. Full article

Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo-Contreras E, Martín J, Machenzie T, Ruiz-Pérez L, González-Packanowska D, Genilloud O, Vicente F, Agyare C, Reyes F. Bioassay-guided isolation of four new antiprotozoal compounds from two Ghanaian mushrooms. Fitoterapia 2018 Jun, 127:341-348. Abstract

González-Menéndez V, Crespo G, De Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O. Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents. Nature.com, Scientific Reports, 2018, 8: 9729. Abstract

Almeida C, Silva Pereira C, González-Menéndez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O. Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor. Appl. Environ. Microbiol., 2018, DOI: 10.1128/AEM.00660-18. Abstract

Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O. Non-geminal aliphatic dihalogenation pattern in dichlorinated diaporthins from Hamigera fusca NRRL 35721. J. Nat. Prod., 2018, 81, 6, 1488–1492. Abstract

Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G. Atmospheric precipitations, hailstone and rainwater, as a novel source of Streptomyces producing bioactive natural products. Front. Microbiol., 2018, 9:773. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Natural product Research, 2018, https://doi.org/10.1080/14786419.2018.1434636. Abstract

Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, Díaz-Navarro C, Pérez-Del Palacio J, García-Fernández M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of LPA_1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018 May 1;133:189-201. Abstract

Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J and Conejo MC. Efficacy of Colistin and Its Combination with Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. Front. Microbiol 2018. 9:912. Abstract

Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N,  Vallorani R, Diaz C, Pérez del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A₂ and Azaspirofuran A, ACS Chem. Neurosci. 2018 DOI: 10.1021/acschemneuro.8b00060. Abstract

Ramos MC, Genilloud O, Reyes F, Vicente F. Drug Discovery from Natural Products for Pancreatic Cancer. Pancreatic Cancer Book. Intech, 2018. DOI: 10.5772/intechopen.76399 Abstract

Sánchez M, González I, Díaz C, Martínez G and Genilloud O. Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains. Front. Microbiol. 2018, 9:369. doi: 10.3389/fmicb.2018.00369. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2018, DOI:10.1080/14786419.2018.1434636. Abstract

Lauritano C, Martín J, de la Cruz M, Reyes F, Romano G, Ianora A. First identification of marine diatoms with anti-tuberculosis activity. Sci. Rep., 2018, 8:2284. Abstract

Sánchez L, Ladrón de Guevara D, Mañas MC, Alén F, Moreno RD, Díaz C, Perez del Palacio J, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla E, Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology (2018), doi: 10.1016/j.neuropharm.2018.01.033. Abstract

Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O and Reyes F. Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp. Mar. Drugs 2018, 16(3), 95; doi:10.3390/md16030095. Abstract

Castillo F, Mackenzie TA, Cautain B. Immunofluorescence analysis by confocal microscopy for detecting endogenous FOXO. Methods in Molecular Biology, DOI 10.1007/978-1.

Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA. Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines. Front. Microbiol., 2018, 9:39. Abstract

2017

Firsova D, Calabro K, Lasserre P, Reyes F, Thomas OP. Isoguanosine Derivatives from the Northeastern Atlantic Sponge Clathria (Microciona) strepsitoxa. Tetrahedron Lett., 2017, 58:4652-4654. Abstract

Genilloud O. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep., 2017,34, 1203-1232, 10.1039/C7NP00026J. Abstract

Genilloud O, Industrial Culture Collections: Gateways from Microbial Diversity to Applications  in Microbial Resources: From Functional Existence in Nature to Applications, Ed J. Wink, 2017, Academic Press 237-256.

Ilic J, Cosic J, Vrandecic K, Dugalic K, Pranjic A, Martin J. Influence of endophytic fungi isolated from symptomless weeds on cherry plants. Mycosphere 2017: 8, 18-30. Full article

Peláez F, de Pedro N, Tormo JR. Chapter 9 of the book: Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications, in Natural Products Targeting Clinically Relevant Enzymes (eds P. B. Andrade, P. Valentão and D. M. Pereira), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2017, Germany. doi: 10.1002/9783527805921

Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G.  Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa. Mar. Drugs, 2017, 15:144. Abstract

Calabro K, Kalahroodi EL, Rodrigues D, Díaz C, Cruz M, Cautain B, Laville R, Reyes F, Pérez T, Soussi B, Thomas OP. Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866). Mar Drugs, Jun 15:199, doi: 10.3390/md15070199. Abstract

Pascual J, García-López M, González I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. International Journal of Systematic and Evolutionary Microbiology, Sept. 67(10), DOI:10.1099/ijsem.0.002227. Abstract

Martínez G, González-Menéndez V, Martín J, Reyes F, Genilloud O, Tormo JR. MASS Studio: A Novel Software Utility to Simplify LC-MS Analyses of Large Sets of Samples for Metabolomics. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10208. Springer, Cham. Abstract

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Correction for Bertoni-Mann et al., “Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris ”. Genome Announcements 2017, 5(43):e01116-17., DOI:10.1128/genomeA.01116-17. Abstract

Almeida C, Bills G, González-Menéndez V, Martin J, Tormo JR, Genilloud O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3(3):45., DOI:10.3390/fermentation3030045. Full paper

Boulaiz H, Ramos MC, Griñán-Lisón C, García-Rubiño ME, Vicente F, Marchal JA, What’s new in the diagnosis of pancreatic cancer: a patent review (2011-present), Expert Opinion. Expert Opin Ther Pat. 2017, Sept 10: 1-16. Full paper

Gonzalez-Menendez V, Martin J, Siles JA, Gonzalez-Tejero MR, Reyes F, Platas G, Tormo JR, Genilloud O. Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula. Mycol Progress 2017, Vol.16, 7:713 – 728. Full paper

Ramos MC, Boulaiz H, Griñan-Lison C, Marchal JA, Vicente F. What's new in treatment of pancreatic cancer: a patent review (2010-2017). Expert Opin Ther Pat. 2017, Jul 12:1-16, Full paper

Serrano R, González V, Rodríguez L, Martín J, Tormo JR, Genilloud O. Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents. Front. Microbiol., 2017, 649, Full paper

Pérez-del Palacio J, Díaz  C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F. Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Front. Pharmacol, 2017, Full paper

Sonnenschein EC, Stierhof M, Goralczyk S, Vabre FM, Pellissier L, Hanssen KE, de la Cruz M, Díaz C, de Witte P, Copmans D, Andersen JH, Hansen E, Kristoffersen V, Tormo JR, Ebel R, Milne BF, Deng H, Gram L, Jaspars M, Tabudravu JN. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron, 2017, Chemical Engineering Journal, 2017, 320: 151-159. Abstract

Vela-Soria F, Gallardo Torres ME, Ballesteros O, Diaz C, Perez J, Navalón A, Fernandez MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Cromatography A, 2017, 1487: 153-161. Abstract

Borges-Argáez R, Cáceres-Farfán M, De Pedro N, Cautain B, Pérez del Palacio P, Vicente F, Genilloud O, Melguizo A, Díaz C, Reyes F, El Aouad N, Sansores-Peraza P. Cytotoxic studies and in vitro effects oftrans -3,4,4’,5-Tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth. Polibotanica, 2017, 43: 165-175. Full paper

Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, De Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MJ, Vicente F, Genilloud O, Tormo JR, Reyes F. Hormonemate Derivatives from the Endophytic Fungus Dothiora sp. J. Nat. Prod., 2017, DOI: 10.1021/acs.jnatprod.6b00680. Full paper

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med., 2017, 05: 366-491. Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, De la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Branimycins B and C, Antibiotics Produced by the abyssal Actinobacterium Pseudonocardia carboxydivorans M-227. J. Nat. Prod., 2017, 80: 569-573. Abstract

De la Cruz M, González I, Parish C, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F. Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes. Front. Microbiol., 2017, 8:343. Fullpaper

Paytubi S, De la Cruz M, Tormo JR, Martín J, González I, González-Menéndez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C. Microbial Natural Products High-Throughput Screening Platform for the Discovery of Molecules with Antibiofilm Properties Against Salmonella. Front. Microbiol., 2017, 8: 326. Fullpaper

González A, Gálvez N, Martín J, Reyes F, Pérez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption. Food Chem., 2017, 228: 374-380. Abstract

2016

Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M. Antimicrobial Activities of Some Actinomycetes Isolated from Different Rhizospheric Soils in Tunisia. Current Microbiology 2016, 73:220-227. Abstract

Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodríguez Quesada L, Machado L, Vicente F, Dallavalle S, Link W. Discovery of a Novel Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS ONE 2016, 11: e0167491. Abstract

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Draft Genome Sequence of Phytopathogenic Fungus Fusarium fujikuroi CF-295141, Isolated from Pinus sylvestris. Genome Annoucements 2016, 4: e01163-16. Abstract

Lacret R, Pérez-Victoria I, Oves-Costales D, de la Cruz M, Domingo E, Martín J, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0170, a new napyradiomycin from Streptomyces sp. strain CA-271078. Mar. Drugs 2016, 14: 188. Abstract

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med. 2016, 81(S01): S1-S381. Abstract

Stierhof M, Hansen KO, Sharma M, Feussner K, Subko K, Fernandez Díaz-Rullo F, Isaksson J, Pérez-Victoria I, Clarke D, Hansen E, Jaspars M, Tabudravu JN. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron 2016, 72: 6929-6934. Abstract

Angulo-Preckler C, Genta-Jouve G, Mahajan N, de la Cruz M, de Pedro N, Reyes F, Iken K, Avila C, Thomas OP. Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft coral Gersemia fruticosa. J. Nat. Prod. 2016, 79: 1132-1136. Abstract

Pascual J, González I, Estévez M, Benito P, Trujillo ME, Genilloud O. Description of Kibdelosporangium banguiense sp. nov., a novel actinomycete isolated from soil of the forest of Pama, on the plateau of Bangui, Central African Republic. Antoine van Leeuwenhoek 2016, 109: 685-695. Abstract

Pascual J, García-López M, Bills GF, Genilloud O. Longimicrobium terrae gen. nov., sp. nov., a novel oligotrophic bacterium of the underrepresented phylum Gemmatimonadetes isolated through a system of miniaturized diffusion chambers. Int. J. Syst. Evol. Microbiol. 2016, 66: 1976-85. Abstract

García-Fontana B, Morale-Santana S, Díaz Navarro C, Rozas-Moreno P, Genilloud O, Vicente Pérez F, Pérez del Palacio J, Muñoz-Torres M. Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study. Talanta 2016, 148: 135-143. Abstract

Sekurova ON, Pérez-Victoria I, Martin J, Degnes KF, Sletta H, Reyes F, Zotchev SB, New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07, Molecules 2016, 21(9): 1131. Abstract

De Pedro N, Cautain B, Cantizani J, Rodriguez L, Vicente F, Tualsi R and Rao Koyyalamudi S. In vitro Neuroprotective Effects of Seven Natural products Against Rotenone-Induced Toxicity in a SH-SY5Y Neuroblastoma Cells Model for Parkinson’s Disease. Pharmacologia 2016, 7: 361-370. Full paper

Vela-Soria I, Jiménez-DíazC, Díaz J, Pérez LM, Iribarne-Durán L, Serrano-López JP, Arrebola1 MF, Fernández N, Olea. Determination of endocrine disrupting chemicals in human milk by dispersive liquid-liquid microextraction. Bioanalysis 2016, 17: 1777-91. Abstract

Algieri F, Rodriguez-Nogales A, Vezza T, Garrido-Mesa J, Garrido-Mesa N, Utrilla MP, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, del Mar Contreras M, Segura-Carretero A, Pérez-Palacio J, Diaz C, Vergara N, Vicente F, Rodriguez-Cabezas ME, Galvez J: Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. J Ethnopharmacol 2016, 190: 142–158. Abstract

Annang F, Genilloud O, Vicente F. Contribution of Natural Products to Drug Discovery in Tropical Diseases. Chapter · July 2016, In book: Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, 75-104

Vicente F, Reyes F, Genilloud O. Fungal secondary metabolites as source of antifungal compounds. In Fungi: Applications and their Management Strategies. Sunil K. Deshmukh, J. K. Misra, Jalpa P. Tewari, Tamas Papp Eds., CRC Press, 2016. ISBN: 9781498724913, 80-116. Summary

Gonzalez-Menéndez V, Pérez-Bonilla M, Pérez-Victoria I, Martín J, Muñoz F, Reyes F, Tormo JR, Genilloud O. Multicomponent analysis of the differential induction of secondary metabolite profiles in fungal endophytes. Molecules 2016, 21(2): 234 Full paper

Pérez del Palacio I, Díaz C, De la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, De Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J. High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries. J. Biomol. Screen. 2016, 21(6): 567-78. Abstract

Pérez-Victoria I, Martín J, Reyes F. Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products. Planta Med 2016, 82: 857–871. Full paper

De Pedro N, Cantizani J, Ortiz-López FJ, González-Menéndez V, Cautain B, Rodríguez L, Bills GF, Reyes F, Genilloud O and Vicente F. Protective Effects of Isolecanoric Acid on Neurodegenerative Diseases. Neuropharmacology, 2016, 101: 538-548. Abstract

Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González V, González I, De Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D. Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products. PLoS ONE 2016, 11(1): e0145812 Abstract

Jaspars, De Pascale D, Andersen JH, Reyes F, Crawford AD, Iannora A. The Marine Biodiscovery Pipeline and Ocean Medicines of Tomorrow. J. Mar. Biol. Assoc. U.K. 2016, 96: 151-158. Full paper

Pascual J, Blanco S, García-López M, García-Salamanca A, Bursakov SA, Genilloud O, Bills OF, Ramos JL, van Dillewijn P. Assessing Bacterial Diversity in the Rhizosphere of Thymus zygis Growing in the Sierra Nevada National Park (Spain) through Culture-Dependent and Independent Approaches. PLoS ONE 2016, 11: e0146558. Abstract

Parra Millán R, Jiménez Mejías ME, Sánchez Encinales V, Ayerbe Algaba R, Gutiérrez Valencia A, Pachón Ibáñez ME, Díaz C, Pérez del Palacio J, López Cortés LF, Pachón J, Smani Y. Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models. Antimicrob Agents Chemother 2016, 60: 4464–4470.2. Abstract

Fernández-Cruz ML, Martín-Cabrejas I, Pérez-del Palacio J, Gaya P, Díaz-Navarro C, Navas JM, Medina M, Arqués JL. In vitro toxicity of reuterin, a potential food biopreservative. Food Chem Toxicol 2016, 96: 155–159.5. Abstract

Ríos Peces S, Díaz Navarro C, Márquez López C, Caba O, Jiménez-Luna C, Melguizo C, Prados JC, Genilloud O, Vicente Pérez F, Pérez del Palacio J. Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma. J Biomol Screen 2016: 1087057116671490.8. Abstract

N’Ait Ousidi A, Ait Itto MY, Auhmani A, Barakate M, Riahi A, Ben El Ayouchia H, Anane H, El Aouad N, De La Cruz M, Díaz C, Vicente F. Synthesis, theoretical and biological studies of some novel Monoterpenic thiazolidin-4-ones. IOSR Journal of Applied Chemistry. Volume 9, Issue 11 Ver. II 2016, 52-61. Full paper

2015

Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN,Murgolo N, Nare B, Olsen D.B, Powles M, Racine F, Su J, Vicente F, Wisniewski D, Xiao L, Hammond M, Young K. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chem Biol. 2015, 22(10): 1362-73. Abstract

Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, De Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA. Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010). Antimicrob Agents Chemother. 2015, 59 (9):5145-53. Full paper

Muñoz-Sáeza E, De Munck Garcíab S, Arahuetes Porterob RM, Vicente F, Ortiz-López FJ, Cantizani J, Gómez Miguel B. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). Neuroscience Letters 2015, 593: 83–89. Abstract

Molina-Santiago C, Udaondo Z, Daddaoua A, Roca A, Martín J, Pérez-Victoria I, Reyes F, Ramos JL. Efflux pump deficient mutants as a platform to search for microbes that produce antibiotics. Microb. Biotechnol. 2015, 8: 716-725. Abstract

Tormo JR, Oves D, Lacret D, Moreno C, DeLa Cruz M, Díaz C, González I, Martín J, Pérez-Victoria, Vicente F, Reyes F, Genilloud O. Marine natural products drug discovery from actinomycetes at Fundacion MEDINA. Planta Medica 2015, 81:11. Abstract

Cautain B, De Pedro N, Schulz C, Pascual J, Sousa TS, Martin J, Pérez-Victoria I, Asensio F, González I, Bills G.F, Reyes F, Genilloud O, Vicente F Identification of the lipodepsipeptide MDN-0066, a novel inhibitor of VHL/HIF pathway produced by a new Pseudomonas species.  PLOS ONE 2015, 10(5): e0125221 Abstract

Figueroa L, Jiménez C, Rodríguez J, Areche C, Chávez R, Heríquez M, De la Cruz M, Díaz C, Segade Y, Vaca I.  3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus. J. Nat Prod. 2015, 78 (4): 919–923 - Abstract

Ortiz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F. Cyclic Colisporifungin and Linear Cavinafungins, three Antifungal Lipopeptides Isolated from Colispora cavincola. J. Nat. Prod. 2015, 78 (3): 468–475 - Abstract

Pascual J, García-López M, Bills GF, Genilloud O Pseudomonas granadensis sp. nov., a new bacterial species isolated from the Tejeda, Almijara and Alhama Natural Park, Granada, Spain. Int. J. Syst. Evol. Microbiol. 2015, 65: 625-632 - Asbtract

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. ACS Infect. Dis. 2015, 1: 59-72 - Full Paper

Cautain B, De Pedro N, Reyes F, Link W  Image-Based Identification of Nuclear Export Inhibitors from Natural Products. Methods Mol. Biol. 2015, 1270: 307-319 - Abstract

Lacret R, Oves-Costales D, Gómez C, Díaz C, de la Cruz M, Pérez-Victoria I,  Vicente F, Genilloud O, Reyes F New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis. Mar. Drugs 2015, 13: 128-140 - Full Paper

Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo J R, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez L M, Navarro M, Gamarro F, González-Pacanowska D High throughput screening platform for Natural Product-based drug discovery against three Neglected Tropical Diseases: human African trypanosomiasis, leishmaniasis and Chagas disease. J. Biomol. Screen. 2015, 20: 82-91 - Abstract

Perez J, Díaz C, Asensio F, Palafox A, Genilloud O, Vicente F A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility. J. Biomol. Screen. 2015, 20(2): 254-264 - Abstract

Cautain B, Hill R, de Pedro N, Link W Components and regulation of nuclear transport processes. FEBS J. 2015, 282(3): 445-462 - Full Paper

2014

Castillo Correa FJ, De Pedro N, Rodriguez Quesada L, Oves Costales D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014; 50 supplement: 6-24

Cantizani J, Ortiz J, Ravipati AS, Rodrigueza L, Cautain B, Zhang L, Reddy N, Nath CE, Vicente F, De Pedro N., and Koyyalamudi SR Screening for Natural Inhibitors in Chinese medicinal plants against Glycogen Synthase Kinase 3β (GSK-3β) Pharmacologia 2014, 5: 205-214

Ondeyka JG, Smith SK, Zink DL, Vicente F, Basilio A, Bills GF, Polishook JD, Garlisi C, Mcguinness D, Smith E, Qiu H, Gill CJ, Donald RGK, Phillips JW, Goetz MA, Singh SB Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin. J. Antibiot 2014, 67(7): 527-531

Genilloud O The re-emerging role of microbial natural products in antibiotic discovery. Antoine van Leeuwenhoek 2014, 106: 173-188

Martín-Rodríguez A J, Reyes F, Martín J, Pérez-Yépez J, León-Barrios M, Couttolenc A, Espinoza C, Trigos Á, Martín V, M. Norte, Fernández J J Inhibition of Bacterial Quorum Sensing by Extracts from Aquatic Fungi: First Report from Marine Endophytes. Mar. Drugs 2014, 12(11): 5503-5526 - Full Paper

Guimarães L A, Jimenez P C, Sousa T da S, Freitas H P S, Rocha D D, Wilke D V, Martín J, Reyes F, Pessoa O D L, Costa-Lotufo L V Chromomycin A2 induces autophagy in melanoma cells Mar. Drugs 2014, 12(12): 5839-55 - Full Paper

Martín J, Crespo G, González-Menéndez V, Pérez-Moreno G, Sánchez-Carrasco P, Pérez-Victoria I, Ruiz-Pérez L M, González-Packanowska D, Vicente F, Genilloud O, Bills G F, Reyes F  MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii. J. Nat. Prod. 2014, 77(9):2118-23. - Abstract

Pascual J, García-López M, Carmona C, da S. Sousa T, de Pedro N, Cautain B, Martín J, Vicente F, Reyes F, F. Bills G, Genilloud O Pseudomonas soli sp. nov., a novel producer of xantholysin congeners. Syst. Appl. Microbiol 2014, 37(6): 412-6 - Abstract

González-Menéndez V, Asensio F, Moreno C, de Pedro N, Monteiro MC, de la Cruz M, Vicente F, Bills G, Reyes F, Genilloud O & Tormo JR Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity. Micology 2014, 5(3): 179-191 - Full Paper

Montiel R, Martín-Cabrejas I, Langa S, El Aouad N, Arqués J L, Reyes F, Medina M. Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.Food Microbiol. 2014, 44: 1-5 - Abstract

Almeida C, El Aouad N, Martín J, Pérez-Victoria I, González-Menéndez V, Platas G, de la Cruz M, Monteiro MC, de Pedro N, Bills GF, Vicente F, Genilloud O, and Reyes F Graminin B, a furanone from the fungus Paraconiothyrium sp. J Antibiot 2014, 67: 421-423 - Abstract

Singh S, Ondeyka J, Buevich A, Williamson R, Zink D, Polishook J, Occi J, Vicente F, Basilio A, Bills G, Donald R, Phillips J, Goetz M Isolation, Structure Elucidation and Biological Activity of Altersolanol P using Staphylococcus aureus Fitness Test Based Genome-wide Screening. J. Nat. Prod. 2014, 77(3): 497-502

Siles JA, Pascual J, González-Menéndez V, Sampedro I, García-Romera I, Bills GF  Short-term dynamics of culturable bacteria in a soil amended with biotransformed dry olive residue. Syst Appl Microbiol 2014, 37(2): 113-20

Siles JA, González-Menéndez V, Platas G, Sampedro I, García-Romera I, Bills GF Effects of Dry Olive Residue Transformed by Coriolopsis floccosa (Polyporaceae) on the Distribution and Dynamic of a Culturable Fungal Soil Community. Microb Ecol 2014, 67(3): 648-58

Hill R, Cautain B, de Pedro N & Link W  Targeting Nucleocytoplasmic Transport in Cancer Therapy. Oncotarget 2014, 5(1): 11-28 - Abstract

Castelli MV, Butassi C, Monteiro MC, Svetaz LA, Vicente F, Zacchino SA Novel antifungal agents: a patent review (2011 - 2014), Exp Op Ther Pat: 24 (3): 1-16 - Abstract

Cautain B, de Pedro N, Murillo Garzón V, Muñoz de Escalona M, González Menéndez C, Tormo JR, Martin J, El Aouad N, Reyes F, Asensio F, Genilloud O, Vicente F and Link W A cell-based strategy using high-content imaging for the discovery of novel nuclear export inhibitors from natural products. J Biomol Screen 2014, 19: 57-65

2013

Chen L, Yue Q, Zhang X, Xiang M, Wang C, Li S, Che Y, Ortiz-López FJ, Bills GF, Liu X and An Z Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics 2013, 14: 339 - Abstract

Gracia AP, Bondoso J, Gaspar H, Xavier JR, Monteiro MC, de la Cruz M, Oves-Costales D, Vicente F, Lage OM Antimicrobial Activity of Heterotrophic Bacterial, Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae). Plos One 2013, 8: 11, e78992 - Abstract

Cautain B, de Pedro N, Muñoz de Escalona M, Tormo JR, Genilloud O, Vicente F HCS Strategy Targeting Dysregulation Of The VHL/HIF Pathway For Drug Discovery. Adv Biosci and Biotechnol 2013, 4: 398-405 - Abstract

Singh SB, Zhang C, Zink DL, Herath K, Ondeyka J, Masurekar P, Jayasuriya H, Goetz MA, Tormo JR, Vicente F, Martín J, González I, Genilloud O Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening. J Antibiot 2013, 66: 599-607 - Abstract

Audoin C, Bonhomme D, Ivanisevic J, de la Cruz M, Cautain B, Monteiro MC, Reyes F, Rios L, Perez T and Thomas OP Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi. Mar Drugs 2013, 11: 1477-1489 - Abstract

Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, and Cuevas C Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds. J Am Chem Soc 2013, 135: 10164-10171 - Abstract

Palomo S, González I, Martín J, de la Cruz M, Vicente F, Reyes F, Tormo JR, Anderson M, Hill RT, Genilloud O Sponge-derived Kocuria and Micrococcus spp. as new sources of thiazolylpeptide antibiotics. Mar Drugs 2013, 11: 1071-1086 - Abstract

Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de la Cruz M, Monteiro MC, Melguizo A, Jiménez E, Vicente F Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific J Trop Med 2013, 6(9): 673-81 - Abstract

Sheo B. Singh John Ondeyka, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González de Val A, Martin J, Reyes F, Wang H, Nielsen Kahn J, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D. Isolation, structure and biological activity of a cyclic lipodepsipeptide phaeofungin from a Phaeosphaeria sp. using the genome-wide Candida albicans Fitness Test.  J Nat Prod 2013, 76: 334-345 - Abstract

García E, Alonso A, Platas G and Sacristán S. The endophytic mycobiota of Arabidopsis thaliana. Fungal divers 2013, 60: 71-89 - Abstract

de Pedro N, Cautain B, Melguizo A, Vicente F, Genilloud O, Peláez F, Tormo JR Mitochondrial complex I inhibitors, acetogenins, induce 5 HepG2 cell death through the induction of the complete 6 apoptotic mitochondrial pathway. J Bioenerg Biomembr 2013, 45: 153-164 - Abstract

De Pedro Montejo N, Cautain B, Melguizo A, Cortes D, Vicente F, Genilloud O, Tormo JR, Peláez F Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I. J Bioenerg Biomembr 20013, 45(1-2): 145-152 - Abstract

Martin J, da S Sousa T, Crespo G, Palomo S, Gonzalez I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Mar Drugs 2013, 11: 387-98 - Abstract

Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de Pedro N, Melguizo A, Cantizani J, Asensio F, Vicente F Anti-proliferative activities of selected Chinese medicinal herbs against human cancer cell lines. Phytopharmacology 2013, 4(2): 206-219 - Abstract

Baral HO, Galán R, Platas G & Tena R Phaeohelotium undulatum comb. nov. and Phaeoh. succineoguttulatum sp. nov., two segregates of the Discinella terrestris aggregate found under Eucalyptus in Spain: taxonomy, molecular biology, ecology and distribution.  Mycosystema 2013, 32(3): 386-428 - Abstract

Pérez J, Díaz C, Salado IG, Pérez DI, Peláez F, Genilloud O, Vicente F Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays. Adv Biosci Biotechnol 2013, 4: 628-639 - Abstract

2012

Singh SB,  Goetz MA,  Smith SK,  Zink DL,  Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, de la Cruz M, Martín J , Vicente F, Genilloud O,  Donald RGK,  Phillips JW Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. Bioorg Med Chem letters 2012, 22: 7127-7130 - Abstract

Fernández-Acero T, Rodríguez-Escudero I, Vicente F,  Monteiro MC, Tormo JR, Cantizani J, Molina M,  Cid VJ A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors. J Biomol Screening 2012, 17(8): 1018-1029 - Abstract

Vicente MF, Bills G, Reyes F, Genilloud O Fundación MEDINA - Investigación en Terapias Innovadoras a partir de Productos Naturales aislados de Microorganismos. Especial Microbiología Industrial y Biotecnología Microbiana. Actualidad SEM 2012,  53: 32-35 - Article

Kai M, González I, Genilloud O, Singh SB, Svatoš A Direct mass spectrometric screening of antibiotics from bacterial surfaces using liquid extraction surface analysis. Rapid Commun. Mass Spectrom. 2012, 26(20): 2477-2482 - Abstract

Genilloud O Current Challenges in the Discovery of Novel Antibacterials from Microbial Natural Products. Recent Pat Antiinfect Drug Discov.  2012, 7(3): 189-204(16) - Abstract

Bills GF, Dombrowski AW and Goetz MA The “FERMEX” method for metabolite-enriched fungal extracts. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.). Meth Mol Biol 2012, 944(5): 79-96 - Abstract

Bills GF, González-Menéndez V, Martin J, Platas G, Fournier J, Peršoh D and Stadler M. Hypoxylon pulicicidumsp. nov. (Ascomycota, Xylariales), a Pantropical Insecticide-Producing Endophyte. PLOS One 2012, 7: e46687 - Abstract

Bills GF, González-Menéndez V and Platas G Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant, Bupleurum gibraltarium (Apiaceae). Mycologia 2012, 104: 962-973 - Abstract

Cueva C, Garcia Ruiz A, González-Rompinelli Bartolomé EB, Martín-Álvarez PJ, Salazar O, Vicente MF,  Bills G and  Moreno-Arribas V Degradation of biogenic amines by vineyard ecosystem fungi. Potential use in winemaking. J Appl Microbiol 2012, 112: 672-682 - Abstract

De la Cruz M, Martín J, González-Menéndez V,  Pérez-Victoria I, Moreno C, Tormo JR, El Aouad N, Guarro J, Vicente F, Reyes F and Bills GF Chemical and physical modulation of antibiotic activity in Emericella species. Chem Biodiv 2012, 9: 1095-1113 - Abstract

El Aouad N, Pérez-Moreno G, Sánchez P, Cantizani J, Ortiz-López FJ, Martín J, González-Menéndez V, Ruiz-Pérez LM, González-Pacanowska D, Vicente F, Bills G and Reyes F Lasionectrin, a Naphthopyrone from a Lasionectria sp. J Nat Prod 2012, 75: 1228-1230 - Abstract

Genilloud O and Vicente F Novel approaches to exploit natural products from microbial resources. InDrug Discovery from Natural Products, Eds. O. Genilloud and F. Vicente, RSC series. 2012, Ch. 11: 221-248 - Book

Genilloud O Genus Micromonospora. In Bergey's Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012 p. vol 5 B: 1039-1057 - Book

Genilloud O Suborder XI. Micromonosporineae and The family Micromonosporaceae. In Bergey's Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012, vol 5 B: 1035-1038 - Book

Herath K, Jayasuriya H, Zink DL,  Sigmund J, Vicente F, de la Cruz M,  Basilio A, Bills GF, Polishook JD,DonaldR, Phillips J,  Goetz M and Singh SB Isolation, structure elucidation and antibacterial activity of methiosetin, a new tetramic acid from a tropical sooty mold (Capnodium sp.). J Nat Prod 2012, 75: 420–424 - Abstract

Monteiro MC, de la Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E,  de Lucas JR, Asensio F,  Valiante V, Brakhage AA, Latgé J-P, Genilloud O and Vicente F A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin. J Biomol Screen 2012, 17: 542-549 - Abstract

Pérez-Victoria I, Martín J, González-Menéndez V, de Pedro N, El Aouad N, Ortiz-López FJ, Tormo JR, Platas G, Vicente F, Bills GF, Genilloud O, Goetz MA and Reyes F Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica. J Nat Prod 2012, 75: 1210-1214 - Abstract

Sánchez-Hidalgo M, Pascual J, de la Cruz M, Martín J, Kath GS, Sigmund JM, Masurekar P, Vicente F, Genilloud O and Bills GF Prescreening bacteria colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system. Antonie van Leeuwenhoek 2012, 102: 361-374 - Abstract

Sánchez Márquez S, Bills GF , Herrero N and Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecol 2012, 5: 289–297 - Abstract

Tormo, JR, Asensio, FJ and Bills (GF) Manipulating filamentous fungus chemical phenotypes by growth in nutritional arrays. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.), Met Mol Biol 2012, vol. 944, 4: 59-78 - Abstract

Oves-Costales D and Challis GL Mining microbial genomes for metabolic products of cryptic pathways. InDrug Discovery from Natural Products, Eds. Genilloud O and Vicente F, RSC series 2012, 8: 140-158 - Abstract

2011

El Aouad N,  Monteiro MC, Pérez-Moreno G, Cantizani J, Moreno C, Martín J, González I, Vicente F, Genilloud O,  González-Packanowska D, Tormo JR,  Reyes F. A new natural Pepstatin from Kitasatospora sp. (Actinomycetales) Planta Medica. 2011, 77: 1345. Abstract

Ferrer M, Guazzaroni ME, Richter M, García-Salamanca A, Yarza P, Suárez-Suárez A, Solano J, Alcaide M, van Dillewijn P, Molina-Henares MA, López-Cortés N, Al-Ramahi Y, Guerrero C, Acosta A, de Eugenio LI, Martínez V, Marques S, Rojo F, Santero E, Genilloud O, Pérez-Pérez J, Rosselló-Móra R, Ramos JL Taxonomic and Functional Metagenomic Profiling of the Microbial Community in the Anoxic Sediment of a Sub-saline Shallow Lake (Laguna de Carrizo, Central Spain). Microb Ecol 2011, 62: 824-37 - Abstract

Cueva C, Moreno-Arribas V, Bartolomé B, Salazar O, Vicente MF & Bills GF  Antibiosis of vineyard ecosystem fungi against food-borne microorganisms. Res Microbiol 2011, 162: 1043–1051 - Abstract

Torres MS, Tadych M, White JF Jr. & Bills GF Dilution-to-extinction cultivation of endophytic fungi and isolation and detection of grass endophytic fungi in different plant parts, Isolation and identification of fungal endophytes. Pgs. 13-18, 153-164. In: Prospects and Applications for Plant-Associated Microbes. A Laboratory Manual, Part B: Fungi. Editors Pirttilä AM & Sorvari S. BioBien Innovations 2011, Paimio, Finland

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho  Santiago Castanys L, Gamarro F, Morales JC, Pérez-Victoria JM, Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry. Bioenergetics 2011, 1808: 717–726 - Abstract

Sánchez Márquez S, Bills GF & Zabalgogeazcoa I Fungal species diversity in juvenile and adult leaves of Eucalyptus globulus from plantations affected by Mycosphaerella leaf disease. Ann Appl Biol 2011, 158: 177-187 - Article

Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F and Pérez-Victoria JM A new ATP binding cassette protein is involved in intracellular haem trafficking in Leishmania. Molecular Microbiology 2011, 79(6): 1430-44- Abstract

Genilloud O, González I, Salazar O, Martín J, Tormo JR, Vicente F Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol, 38: 375–389 - Abstract

Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE and Bills GF Confronting the Challenges of Natural Product-Based Antifungal Discovery. Chem Biol 2011, 18: 148-164 - Abstract

Xu D, Ondeyka J, Harris GH, Zink D, Nielsen Kahn J, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, and Singh SB Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test. J Nat Prod 2011, 74 (8): 1721-1730 - Abstract

Gabriel Moreno, Maria-Natividad Blanco, Julia Checa,  Gonzalo Platas,  Fernando Peláez Taxonomic and phylogenetic revision of three rare irpicoid species within the Meruliaceae. Mycol Progress 2011, 10: 481-491 - Abstract

Peláez F, Collado J, Platas G, Overy DP, Martín J, Vicente F, González del Val A, Basilio A, de la Cruz M, Tormo JR, Fillola A, Arenal F, Villareal M, Rubio V, Baral HO, Galán R and Bills GF The phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensis. Mycology 2011, 2: 1–17 - Abstract

Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RGK, and Singh SB Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus. Chem Biol 2011, 18: 955–965 - Abstract

Sánchez Márquez S, Bills GF, Herrero N, Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecology 2011 , 5(3): 289–297 - Abstract

Tijerino A, Cardoza RE, Moraga J, Malmierca MG, Vicente F, Aleu J, Collado IG, Gutiérrez S, Monte E, Hermosa R Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. Fungal Genet Biol 2011, 48: 285–296 - Abstract

2010

El Aouad N, Ortiz-Lopez J, Martín J, Tormo JR, Goetz M and Genilloud O. New semi –automated method for the creation of a microbial fraction collection developed at Fundación MEDINA. Planta Medica 2010, 76: 1319 - Abstract

Ayers S, Zink DL, Mohn K, Powell JS, Brown CM, Bills G, Grund A, Thompson D and Singh SB Anthelmintic constituents of Clonostachys candelabrum. J  Antibiot, 2010, 63: 119-122 - Abstract

Cueva C, Victoria Moreno-Arribas M, Martín-Alvarez PJ, Bills G, Vicente F, Basilio A, Lopez Rivas C, Requena T, Rodriguez JM and Bartolome B Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol 2010, 161: 372-382 - Abstract

Duetz W, Chase M and Bills G Miniaturization of fermentations. In Manual of Industrial Microbiology and Biotechnology, 3rd ed eds. Demain A, Davies J and Baltz R. pp.99-116. Washington, DC 2010: ASM Press - Book

Goetz MA, Zhang C, Zink DL, Arocho M, Vicente F, Bills GF, Polishook J, Dorso K, Onishi R, Gill C, Hickey E, Lee S, Ball R, Skwish S, Donald RGK, Phillips JW and Singh SB Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling. J Antibiot 2010, 63: 512-518 - Abstract

Márquez SS, Bills GF, Acuna LD and Zabalgogeazcoa I Endophytic mycobiota of leaves and roots of the grass Holcus lanatus. Fungal Diversity 2010, 41: 115-123 - Abstract

Peterson SW, Jurjevic Z, Bills GF, Stchigel AM, Guarro J and Vega FE Genus Hamigera, six new species and multilocus DNA sequence based phylogeny. Mycologia 2010, 102: 847-864 - Abstract

2009

Bills G, Overy DP, Genilloud O and Peláez F Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defense and antagonism. In Defensive Mutualism in Microbial Symbiosis eds. White JF and Torres MS. pp.257-297 Boca Raton, USA 2010: CRC Press - Book

Bills GF, Martín J, Collado J, Platas G, Overy D, Tormo JR, Vicente F, Verkleij G and Crous P Measuring the distribution and diversity of antibiosis and secondary metabolites in the filamentous fungi. Society of Industrial Microbiology News 2009, 59: 133-147 - Abstract

Bills GF, Platas G, Overy D, Collado J, Fillola A, Jiménez MR, Martín J, Val AGd, Vicente F, Tormo JR, Peláez F, Calati K, Harris G, Parish C, Xu D and Roemer T Discovery of the parnafungins, antifungal metabolites that inhibit mRNA poly-adenylation, from the Fusarium larvarum complex and other hypocrealean fungi. Mycologia 2009, 101: 445-469 - Abstract

Blanco MN, Moreno G, Checa J, Platas G and Peláez F Taxonomic and phylogenetic revision of Coniophora arachnoidea, C. opuntiae, and C. prasinoides. Mycotaxon 2009, 108: 467-477 - Abstract

Donald RGK, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, Martin J, Lee SH, Taylor I, Robbins D, Malone C, Wang LS, Zamudio CS, Youngman PJ and Phillips JW  AStaphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem Biol 2009, 16: 826-836 - Abstract

Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu DM, Roemer T and Singh SB (2009) Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp. Bioorg Med Chem 2009, 17: 1361-1369 - Abstract

Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, González A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu DM, Roemer T and Singh SB Isolation, structure elucidation, and biological activity of virgineone from Lachnum virgineum using the genome-wide Candida albicans fitness fest. J Nat Prod 2009, 72: 136-141

Overy D, Calati K, Kahn JN, Hsu M-J, Martin J, Collado J, Roemer T, Harris G and Parish CA Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products. Bioorg Med Chem Lett  2009, 19: 1224-1227 - Abstract

Parish CA, de la Cruz M, Smith SK, Zink D, Baxter J, Tucker-Samaras S, Collado J, Platas G, Bills G, Díez MT, Vicente F, Peláez F and Wilson K Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum. J Nat Prod 2009, 72: 59-62 - Abstract

Platas G, González V, Collado J, Martín J, Montes C and Peláez F Ascription of poorly defined taxa to taxonomic entities using molecular phylogenies: a case study on Nodulisporium sp producers of nodulisporic acid. Mycotaxon 2009, 109: 443-460 - Abstract

Rojas JL, Martín J, Tormo JR, Vicente F, Brunati M, Ciciliato I, Losi D, Trappen SV, Mergaert J, Swings J, Marinelli F and Genilloud O Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites. Marine Genomics 2009, 2: 33-41 - Abstract

Singh SB, Jayasuriya H, Zink D, Basilio A, Vicente F, Collado J, Bills G, Lee Goldman M, Motyl M, Huber J, Dezeny G & Byrne K Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy. J Antibiot, 2009, 62: 265-269 - Abstract

Singh SB, Genilloud O and Peláez F NP structural diversity II - Secondary metabolite sources, evolution and selected molecular structures: Terrestrial micro-organisms – bacteria. In Comprehensive Natural Products Chemistry II eds. Moore, B and CrewsP., 2009, 109-140. UK: Elsevier - Book

Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S and Genilloud O Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered fromStreptomyces lucensis MA7349 using an antisense strategy. J Nat Prod 2009, 72: 345-352 - Abstract

Vicente F, Basilio A, Platas G, Collado J, Bills GF, González del Val A, Martín J, Tormo JR, Harris GH, Zink DL, Justice M, Kahn JN and Peláez F Distribution of the antifungal agents sordarins across filamentous fungi. Mycol Res 2009, 113: 754-770 - Abstract

Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Salazar O, Genilloud O, Dorso K, Motyl M, Byrne K and Singh SB Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4. J Antibiot 2009, 62: 55-61 - Abstract

Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy. Bioorg Med Chem 2009, 17: 2162-2166 - Abstrac

2008

Ayers S, Zink DL, Powell JS, Brown CM, Grund A, Bills GF, Platas G, Thompson D and Singh SB Noreupenifeldin, a tropolone from an unidentified ascomycete. J Nat Prod 2008, 71: 457-459 - Abstract

Bills GF, Platas G, Fillola A, Jiménez MR, Collado J, Vicente F, Martín J, González A, Bur-Zimmermann J, Tormo JR and Peláez F Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays. J Appl Microbiol 2008, 104: 1644-1658 - Abstract

Jiang B, Xu DM, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu WQ, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Peláez F, Díez MT, Kauffman S, Becker J, Harris G, Liberator P and Roemer T PAP inhibitor with in vivo efficacy identified byCandida albicans genetic profiling of natural products. Chem Biol 2008, 15: 363-374 - Abstract

Moreno G, Platas G, Peláez F, Bernedo M, Vargas A, Daza A, Santamaria C, Camacho M, de la Osa LR and Manjon JL Molecular phylogenetic analysis shows that Amanita ponderosa and A. curtipes are distinct species. Mycol Prog 2008, 7: 41-47 - Abstract

Ortega A, Moreno G, Platas G and Peláez F A new Armillaria mellea variant from tops of coastal sand dunes in southern Spain. Mycotaxon2008, 104: 349–364 - Abstract

Parish CA, Smith SK, Calati K, Zink D, Wilson K, Roemer T, Jiang B, Xu DM, Bills G, Platas G, Peláez F, Díez MT, Tsou N, McKeown AE, Ball RG, Powles MA, Yeung L, Liberator P and Harris G Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc 2008, 130: 7060-7066 - Abstract

Peláez F, González V, Platas G, Sánchez-Ballesteros J and Rubio V Molecular phylogenetic studies within the Xylariaceae based on ribosomal DNA sequences. Fungal Divers 2008, 31: 111-134 - Abstract

Rincón A, Arenal F, González I, Manrique E, Lucas MM Pueyo JJ Diversity of rhizobial bacteria isolated from nodules of the gypsophyte Ononis tridentata L. growing in Spanish soils. Microb Ecol 2008, 56: 223-233 Abstract

Rossman AY, Farr DF, Platas G and Newcombe G Hydropisphaera fungicola Rossman, Farr & Newcombe sp. nov. Fungal Planet 2008, 24 - Article

Ruibal C, Platas G and Bills GF High diversity and morphological convergence among melanised fungi from rock formations in the Central Mountain System of Spain. Persoonia 2008, 21: 93-110 - Article

Sánchez S, Bills GF and Zabalgogeazcoa I Fungal endophytes from two sympatric coastal grasses. Fungal Divers 2008, 33: 87-100 - Article

Singh SB, Zink DL, Herath KB, Salazar O and Genilloud O Discovery and antibacterial activity of lucensimycin C from Streptomyces lucensis. Tetrahedron Lett 2008, 49: 2616-2619 - Abstract

Zhang CW, Occi J, Masurekar P, Barrett JF, Zink DL, Smith S, Onishi R, Ha SH, Salazar O, Genilloud O, Basilio A, Vicente F, Gill C, Hickey EJ, Dorso K, Motyl M and Singh SB Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347. J Am Chem Soc 2008, 130: 12102-12110 - Abstract

Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Bills G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure, and antibacterial activity of phaeosphenone from a Phaeosphaeria sp discovered by antisense strategy. J Nat Prod 2008, 71: 1304-1307 - Abstract